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Article

Tsc1 regulates tight junction independent of mTORC1

23 Jul 2021

Abstract excerpt

Tuberous sclerosis complex 1 (Tsc1) is a tumor suppressor that functions together with Tsc2 to negatively regulate the mechanistic target of rapamycin complex 1 (mTORC1) activity. Here, we show that Tsc1 has a critical role in the tight junction (TJ) formation of epithelium, independent of its role in Tsc2 and mTORC1 regulation. When an epithelial cell establishes contact with neighboring cells, Tsc1, but not...

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PMID: 34301883
DOI: 10.1073/pnas.2020891118

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