Article
The structure of cytomegalovirus immune modulator UL141 highlights structural Ig-fold versatility for receptor binding.
Acta crystallographica. Section D, Biological crystallography - 1 Mar 2014
Nemčovičová Ivana, Zajonc Dirk M
Abstract excerpt
Natural killer (NK) cells are critical components of the innate immune system as they rapidly detect and destroy infected cells. To avoid immune recognition and to allow long-term persistence in the host, Human cytomegalovirus (HCMV) has evolved a number of genes to evade or inhibit immune effector pathways. In particular, UL141 can inhibit cell-surface expression of both the NK cell-activating ligand CD155 as...
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