Article
Isoform specific FBXW7 mediates NOTCH1 Abruptex mutation C1133Y deregulation in oral squamous cell carcinoma.
Cell death & disease - 13 Aug 2020
Zheng Yang, Song An, Wang Chundi, Zhang Wei, Liang Dong, Ding Xu, Li Gang, Zhang Hongchuang, Zhang Wei, Du Yifei, Zhou Junbo, Wu Heming, Wu Yunong, Song Xiaomeng
Abstract excerpt
Our group previously identified that the NOTCH1 Abruptex domain contains the most mutations in Chinese OSCC patients, including a hotspot mutation (C1133Y). FBXW7 is an E3 ubiquitin ligase that regulates a network of proteins, including NOTCH1, via degradation. In this study, we first described the co-localization of isoform specific FBXW7-FBXW7β and NOTCH1C1133Y mutation in the same cytoplasmic sites. Gain- and...
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