Article
The endoplasmic reticulum stress response is stimulated through the continuous activation of transcription factors ATF6 and XBP1 in Ins2+/Akita pancreatic beta cells.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Mar 2004
Nozaki Jun ichi, Kubota Hiroshi, Yoshida Hiderou, Naitoh Motoko, Goji Junko, Yoshinaga Takeo, Mori Kazutoshi, Koizumi Akio, Nagata Kazuhiro
Abstract excerpt
The dominant C96Y mutation of one of the two murine insulin genes, Ins2, causes diabetes mellitus in 'Akita' mice. Here we established pancreatic islet beta cell lines from heterozygous mice (Ins2+/Akita). Western blot analysis of endoplasmic reticulum (ER) molecular chaperones indicated that Grp78, Grp94 and Orp150 are significantly increased in Ins2+/Akita cells compared with wild-type (Ins2+/+) cells. Reporter...
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