Article
Comparative molecular analysis of primary and recurrent oligodendroglioma that acquired imbalanced 1p/19q codeletion and TP53 mutation: a case report.
Acta neurochirurgica - 1 Dec 2020
Ono Takahiro, Reinhardt Annekathrin, Takahashi Masataka, Nanjo Hiroshi, Kamataki Akihisa, von Deimling Andreas, Shimizu Hiroaki
Abstract excerpt
Oligodendroglioma is defined by IDH mutation and 1p/19q codeletion. Normal TP53 status is also its molecular feature. We report a case of oligodendroglioma that acquired imbalanced 1p/19q codeletion and TP53 mutation at recurrence after temozolomide therapy. The primary and recurrent tumors shared IDH1 and TERT promoter mutations. Although 1p/19q was codeleted in the primary tumor, it was imbalanced in the...
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