Article
Molecular pathology and clinical characteristics of oligodendroglial neoplasms.
Annals of neurology - 1 Jun 2005
Walker Carol, du Plessis Daniel G, Joyce Kathy A, Fildes Diane, Gee Abigail, Haylock Brian, Husband David, Smith Trevor, Broome John, Warnke Peter C
Abstract excerpt
To evaluate the role of molecular genetics in the routine clinic, we investigated allelic imbalance at 1p36, 19q13, 17p13, 10p12-15, and 10q22-26 and p53 mutation in 100 oligodendroglial neoplasms diagnosed at a single treatment center between 2000 and 2003. The -1p/-19q genotype, seen in 64, 34, 77, and 30% of OII, OAII, OIII, and OAIII respectively, was inversely related to p53 mutation and 17p13 loss. Genotype...
Topics
- Adult
- Aged
- Brain Neoplasms
- Chromosomes, Human, Pair 1
- Chromosomes, Human, Pair 10
- Chromosomes, Human, Pair 17
- Chromosomes, Human, Pair 19
- Female
- Genetic Testing
- Genotype
- Humans
- Male
- Middle Aged
- Neoplasm Recurrence, Local