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Article

Genetically heterogeneous glioblastoma recurring with disappearance of 1p/19q losses: case report.

Neurosurgery - 1 Jul 2007

Ito Motokazu, Wakabayashi Toshihiko, Natsume Atsushi, Hatano Hisashi, Fujii Masazumi, Yoshida Jun

Abstract excerpt

OBJECTIVE: Intratumor heterogeneity is of great importance in many clinical aspects of glioma biology, including tumor grading, therapeutic response, and recurrence. Modifications in the genetic features of a specific primary tumor recurring after chemo- and radiotherapy are poorly understood. We report a recurrent glioblastoma case exhibiting loss of heterozygosity (LOH) on chromosome 10q, while the primary...

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PMID: 17621007
DOI: 10.1227/01.neu.0000279739.53425.5c

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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