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Genomic alterations in blast phase of BCR::ABL1-negative myeloproliferative neoplasms.

International journal of laboratory hematology - 1 Dec 2023

Chen Dong, Weinberg Olga K

Abstract excerpt

The blast phase of BCR::ABL1-negative myeloproliferative neoplasm (MPN-BP) represents the final stage of the disease, which is complicated by complex genomic alterations. These alterations result from sequence changes in genetic material (DNA, RNA) and can lead to either a gain or loss of function of encoded proteins, such as adaptor proteins, enzymes, components of spliceosomes, cell cycle checkpoints...

Topics

Humans
Blast Crisis
Myeloproliferative Disorders
Mutation
Genomics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 37867386
DOI: 10.1111/ijlh.14184

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