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Article

NRF2 Dysregulation in Hepatocellular Carcinoma and Ischemia: A Cohort Study and Laboratory Investigation.

Radiology - 1 Oct 2020

Ziv Etay, Zhang Yiru, Kelly Luke, Nikolovski Ines, Boas F Edward, Erinjeri Joseph P, Cai Liqun, Petre Elena N, Brody Lynn A, Covey Anne M, Getrajdman George, Harding James J, Sofocleous Constantinos, Abou-Alfa Ghassan K, Solomon Stephen B, Brown Karen T, Yarmohammadi Hooman

Abstract excerpt

Background Intermediate stage hepatocellular carcinomas (HCCs) are treated by inducing ischemic cell death with transarterial embolization (TAE) or transarterial chemoembolization (TACE). A subset of HCCs harbor nuclear factor E2-related factor 2 (NRF2), a major regulator of the oxidative stress response implicated in cell survival after ischemia. NRF2-mutated HCC response to TAE and/or TACE is unknown. Purpose...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32780006
DOI: 10.1148/radiol.2020200201
PMCID: PMC7526944

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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