Back to search

Article

Cannabigerol potentiates rivoceranib in hepatocellular carcinoma through a receptor-independent ER stress–calcium program that collapses the E2F1–FOXM1 axis

2026-08-20

Abstract excerpt

<title>Abstract</title> <p>Hepatocellular carcinoma (HCC) remains a leading cause of cancer mortality, and many patients show limited durable responses to systemic therapy. Rivoceranib (apatinib), an oral vascular endothelial growth factor receptor 2 (VEGFR2) tyrosine kinase inhibitor, has clinical activity in advanced HCC, particularly with PD-1 blockade, yet incomplete responses and resistance persist. Because...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
1dcbd7f8-b76d-5440-8b28-3718459bbaa0
DOI
10.21203/rs.3.rs-10470669/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Cannabigerol potentiates rivoceranib in hepatocellular carcinoma through a receptor-independent ER stress–calcium program that collapses the E2F1–FOXM1 axisDOI 10.21203/rs.3.rs-10470669/v1
The mechanism of CPT1A involved in hepatocellular carcinoma growth and Bufalin regulates malignant behavior of hepatocellular carcinoma via CPT1ASemantic proximity
Cannabidiol potentiates p53-driven autophagic cell death in non-small cell lung cancer following DNA damage: a novel synergistic approach beyond canonical pathwaysSemantic proximity
The strengths and limits of cannabinoids and their receptors in cancer: Insights into the role of tumorigenesis-underlying mechanisms and therapeutic aspectsSemantic proximity
Cannabidiol reverts the malignant phenotype of hepatocellular carcinoma cells via the GPR55/TP53/MAPK axis.Semantic proximity
Diterpenoid Vinigrol specifically activates ATF4/DDIT3-mediated PERK arm of unfolded protein response to drive non-apoptotic death of breast cancer cellsSemantic proximity
Cannabis Biomolecule Effects on Cancer Cells and Cancer Stem Cells: Cytotoxic, Anti-Proliferative, and Anti-Migratory ActivitiesSemantic proximity
Network pharmacological analysis of corosolic acid inhibits hepatocellular carcinoma progression through P4HA2Semantic proximity
Exploring the mechanism of Naringenin in the treatment of hepatocellular carcinoma based on mRNA sequencing and experimental validationSemantic proximity
Evaluating the Antitumor Potential of Cannabichromene, Cannabigerol, and Related Compounds from Cannabis sativa and Piper nigrum Against Malignant Glioma: An In Silico to In Vitro ApproachSemantic proximity
Transcriptomic Insights into the Antitumor Mechanism of Bufalin in Hepatocellular Carcinoma Cell HepG2Semantic proximity
Transcriptome Analysis of Cisplatin, Cannabidiol, and Intermittent Serum Starvation Alone and in Various Combinations on Colorectal Cancer CellsSemantic proximity
Multi-Target Inhibition of Hepatocellular Carcinoma via DIBP from Glycyrrhiza uralensis: A Systems Biology and Experimental ApproachSemantic proximity
Select a neighboring publication to make it the new centre.