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Article

Trans-ancestral dissection of urate- and gout-associated major loci SLC2A9 and ABCG2 reveals primate-specific regulatory effects.

Journal of human genetics - 1 Feb 2021

Takei Riku, Cadzow Murray, Markie David, Bixley Matt, Phipps-Green Amanda, Major Tanya J, Li Changgui, Choi Hyon K, Li Zhiqiang, Hu Hua, Guo Hui, He Meian, Shi Yongyong, Stamp Lisa K, Dalbeth Nicola, Merriman Tony R, Wei Wen-Hua

Abstract excerpt

Gout is a complex inflammatory arthritis affecting ~20% of people with an elevated serum urate level (hyperuricemia). Gout and hyperuricemia are essentially specific to humans and other higher primates, with varied prevalence across ancestral groups. SLC2A9 and ABCG2 are major loci associated with both urate and gout in multiple ancestral groups. However, fine mapping has been challenging due to extensive linkage...

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 2
Share to Glucose Transport Proteins, Facilitative

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hyperuricemia

Share to Primates

Share to Quantitative Trait, Heritable

Share to Regulatory Sequences, Nucleic Acid

Share to Uric Acid

Source

Identifiers

PMID: 32778763
DOI: 10.1038/s10038-020-0821-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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