Article
Association analysis of the SLC22A11 (organic anion transporter 4) and SLC22A12 (urate transporter 1) urate transporter locus with gout in New Zealand case-control sample sets reveals multiple ancestral-specific effects.
Arthritis research & therapy - 1 Jan 2013
Flynn Tanya J, Phipps-Green Amanda, Hollis-Moffatt Jade E, Merriman Marilyn E, Topless Ruth, Montgomery Grant, Chapman Brett, Stamp Lisa K, Dalbeth Nicola, Merriman Tony R
Abstract excerpt
INTRODUCTION: There is inconsistent association between urate transporters SLC22A11 (organic anion transporter 4 (OAT4)) and SLC22A12 (urate transporter 1 (URAT1)) and risk of gout. New Zealand (NZ) Māori and Pacific Island people have higher serum urate and more severe gout than European people. The aim of this study was to test genetic variation across the SLC22A11/SLC22A12 locus for association with risk of...
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