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Article

Discoidin Domain Receptor 1 is a therapeutic target for neurodegenerative diseases

5 Aug 2020

Abstract excerpt

The role of Discoidin Domain Receptors (DDRs) is poorly understood in neurodegeneration. DDRs are upregulated in Alzheimer's and Parkinson's disease (PD), and DDRs knockdown reduces neurotoxic protein levels. Here we show that potent and preferential DDR1 inhibitors reduce neurotoxic protein levels in vitro and in vivo. Partial or complete deletion or inhibition of DDR1 in a mouse model challenged with...

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PMID: 32776088
DOI: 10.1093/hmg/ddaa177

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