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Article

Discoidin domain receptor inhibition reduces neuropathology and attenuates inflammation in neurodegeneration models.

Journal of neuroimmunology - 15 Oct 2017

Hebron Michaeline, Peyton Margo, Liu Xiaoguang, Gao Xiaokong, Wang Ruochong, Lonskaya Irina, Moussa Charbel E-H

Abstract excerpt

The role of cell surface tyrosine kinase collagen-activated receptors known as discoidin domain receptors (DDRs) is unknown in neurodegenerative diseases. We detect up-regulation in DDRs level in post-mortem Alzheimer and Parkinson brains. Lentiviral shRNA knockdown of DDR1 and DDR2 reduces the levels of α-synuclein, tau, and β-amyloid and prevents cell loss in vivo and in vitro. DDR1 and DDR2 knockdown alters...

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Source

Identifiers

PMID: 28863860
DOI: 10.1016/j.jneuroim.2017.07.009

Genes

DDR1
DDR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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