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Article

Effects of DISC1 on Alzheimer's disease cell models assessed by iTRAQ proteomics analysis.

Bioscience reports - 28 Jan 2022

Lu Jiajie, Huang Rihong, Peng Yuecheng, Wang Haojian, Feng Zejia, Fan Yongyang, Zeng Zhaorong, Wang Yezhong, Wei Jiana, Wang Zhaotao

Abstract excerpt

Alzheimer's disease (AD) is a form of neurodegenerative disease in the elderly with no cure at present. In a previous study, we found that the scaffold protein, disrupted in Schizophrenia 1 (DISC1) is down-regulated in the AD brains, and ectopic expression of DISC1 can delay the progression of AD by protecting synaptic plasticity and down-regulating BACE1. However, the underlying mechanisms remain not to be...

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Identifiers

PMID: 34981809
DOI: 10.1042/BSR20211150
PMCID: PMC8753346

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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