Nurr1 deficiency impairs autophagy-lysosomal function through GBA-dependent transcriptional regulation in Parkinson’s disease pathogenesis

Abstract excerpt

Introduction The autophagy-lysosomal pathway (ALP) dysfunction and lysosomal impairment contribute to the pathogenesis of Parkinson’s disease (PD). Nuclear receptor related protein 1 (Nurr1) maintains the differentiation and maturation of dopaminergic neurons, and mutants or polymorphism in Nurr1 is associated with familial and sporadic PD. Previous studies on Nurr1 have mainly focused on the development and...

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