Neurodegenerative disease-associated microRNAs acting as signaling molecules modulate CNS neuron structure and viability

Abstract excerpt

BACKGROUND: Dysregulation of microRNA (miRNA) expression in the brain is a common feature of neurodegenerative diseases. Beyond their conventional role in regulating gene expression at the post-transcriptional level, certain miRNAs can act extracellularly as signaling molecules. Our study elucidates the identity of such miRNA species serving as ligands for membrane receptors expressed in central nervous system...

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