Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Upregulated Expression of MicroRNA-204-5p Leads to the Death of Dopaminergic Cells by Targeting DYRK1A-Mediated Apoptotic Signaling Cascade

13 Sept 2019

Abstract excerpt

MicroRNAs (miRs) downregulate or upregulate the mRNA level by binding to the 3'-untranslated region (3'UTR) of target gene. Dysregulated miR levels can be used as biomarkers of Parkinson's disease (PD) and could participate in the etiology of PD. In the present study, 45 brain-enriched miRs were evaluated in serum samples from 50 normal subjects and 50 sporadic PD patients. The level of miR-204-5p was upregulated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Nerve injury and regeneration
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31572127
DOI: 10.3389/fncel.2019.00399

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Upregulated Expression of MicroRNA-204-5p Leads to the Death of Dopaminergic Cells by Targeting DYRK1A-Mediated Apoptotic Signaling CascadePMID 31572127Read ↗

ROLE OF MICRORNAS IN THE PATHOGENESIS OF PARKINSON'S DISEASESemantic proximity Read ↗

Aberrant Expression of Circulating MicroRNA Leads to the Dysregulation of Alpha-Synuclein and Other Pathogenic Genes in Parkinson’s DiseaseSemantic proximity Read ↗

Understanding the Involvement of microRNAs in Mitochondrial Dysfunction and Their Role as Potential Biomarkers and Therapeutic Targets in Parkinson’s DiseaseSemantic proximity Read ↗

MicroRNA-4639 Is a Regulator of DJ-1 Expression and a Potential Early Diagnostic Marker for Parkinson’s DiseaseSemantic proximity Read ↗

High Throughput Sequencing Identifies MicroRNAs Mediating α-Synuclein Toxicity by Targeting Neuroactive-Ligand Receptor Interaction Pathway in Early Stage of Drosophila Parkinson's Disease ModelSemantic proximity Read ↗

Autophagy‑regulating miRNAs: Novel therapeutic targets for Parkinson's disease (Review)Semantic proximity Read ↗

miR-214-3p promotes the pathogenesis of Parkinson's disease by inhibiting autophagySemantic proximity Read ↗

MicroRNAs in the pathogenesis of neurodegenerative disorders: Potential as therapeutic targetsSemantic proximity Read ↗

Regulatory miRNA–mRNA Networks in Parkinson’s DiseaseSemantic proximity Read ↗

miR-132-5p regulates apoptosis and autophagy in MPTP model of Parkinson’s disease by targeting ULK1Semantic proximity Read ↗

MicroRNA-326 Inhibits Apoptosis and Promotes Proliferation of Dopaminergic Neurons in Parkinson’s Disease Through Suppression of KLK7-Mediated MAPK Signaling PathwaySemantic proximity Read ↗

MicroRNA-599 regulates the development of Parkinson's disease through mediating LRRK2 expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.