Article

Inhibition of discoidin domain receptor (DDR)-1 with nilotinib induces autophagy and reduces inflammation and vascular fibrosis in Alzheimer’s disease

2023-03-22

Abstract excerpt

Discoidin Domain Receptor (DDR)-1 is activated by collagen. Nilotinib is a tyrosine kinase inhibitor that is FDA-approved for leukemia and potently inhibits DDR-1. Individuals diagnosed with mild-moderate Alzheimer’s disease (AD) treated with nilotinib (versus placebo) for 12 months showed reduction of amyloid plaque and cerebrospinal fluid (CSF) amyloid, and attenuation of dopamine catabolism and hippocampal volu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 589ae5a5-5b08-57dc-ac68-909b635131d0
DOI: 10.21203/rs.3.rs-2705486/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inhibition of discoidin domain receptor (DDR)-1 with nilotinib induces autophagy and reduces inflammation and vascular fibrosis in Alzheimer’s diseaseDOI 10.21203/rs.3.rs-2705486/v1Read

Discoidin Domain Receptor 1 is a therapeutic target for neurodegenerative diseasesSemantic proximity Read

Discoidin domain receptor inhibition reduces neuropathology and attenuates inflammation in neurodegeneration models.Semantic proximity Read

Alteration of Autophagy and Glial Activity in Nilotinib-Treated Huntington’s Disease PatientsSemantic proximity Read

WITHDRAWN: GeneTerrain-GMM Unmasks a Coordinated Neuroinflammatory and Cell Death Network Perturbed by Dasatinib in a Human Neuronal Model of Alzheimer’s DiseaseSemantic proximity Read

Single molecule array measures of LRRK2 kinase activity in serum link Parkinson’s disease severity to peripheral inflammationSemantic proximity Read

TYK2 as a novel therapeutic target in Alzheimer’s Disease with TDP-43 inclusionsSemantic proximity Read

Neurodegenerative disease-associated microRNAs acting as signaling molecules modulate CNS neuron structure and viabilitySemantic proximity Read

Differential LRRK2 Signalling and Gene Expression in WT-LRRK2 and G2019S-LRRK2 Mouse Microglia Treated with Zymosan and MLi2Semantic proximity Read

LAX1 as a Core Biomarker in Alzheimer's Disease and Periodontitis via the STAT signaling pathwaySemantic proximity Read

Soluble Immune Factor Profiles in Blood and CSF Associated with LRRK2 Mutations and Parkinson’s DiseaseSemantic proximity Read

The neuroinflammatory biomarker YKL-40 for neurodegenerative diseases: advances in developmentSemantic proximity Read

A Phase I, Randomized, Double-Blind, Placebo-Controlled Trial of Intracisternal Engineered Autologous Exosomes (NV-101) to Restore Neuronal Proteostasis in Early Alzheimer’s Disease: The RESTORE ProtocolSemantic proximity Read