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Article

High-throughput assessment of mutations generated by genome editing in induced pluripotent stem cells by high-resolution melting analysis.

Cytotherapy - 1 Oct 2020

Pham Quang T, Raad Suleen, Mangahas Chenicka-Lyn, M'Callum Marie-Agnès, Raggi Claudia, Paganelli Massimiliano

Abstract excerpt

BACKGROUND AND AIMS: Genome editing of induced pluripotent stem cells (iPSCs) holds great potential for both disease modeling and regenerative medicine. Although clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 provides an efficient and precise genome editing tool, iPSCs are especially difficult to transfect, resulting in a small percentage of cells carrying the...

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Identifiers

PMID: 32768274
DOI: 10.1016/j.jcyt.2020.06.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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