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Article

Reduced CYP2D6 activity is a negative risk factor for methamphetamine dependence.

Neuroscience letters - 21 Mar 2008

Otani Kyohei, Ujike Hiroshi, Sakai Ayumu, Okahisa Yuko, Kotaka Tatsuya, Inada Toshiya, Harano Mutsuo, Komiyama Tokutaro, Hori Toru, Yamada Mitsuhiko, Sekine Yoshimoto, Iwata Nakao, Iyo Masaomi, Sora Ichiro, Ozaki Norio, Kuroda Shigetoshi

Abstract excerpt

Because methamphetamine (METH) is metabolized by CYP2D6 at the first step of hydroxylation and demethylation, it is possible that functional variants of CYP2D6 alter susceptibility to methamphetamine-induced dependence. We genotyped CYP2D6*1, *4, *5, *10, and *14 for 202 patients with METH depend...

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Share to Amphetamine-Related Disorders
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18280655
DOI: 10.1016/j.neulet.2008.01.033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18280655-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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