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Small Molecule Adjuvants Potentiate Colistin Activity and Attenuate Resistance Development in Escherichia coli by Affecting pmrAB System

1 Jul 2020

Abstract excerpt

Background: Colistin is one of the last-resort antibiotics to treat multi-drug resistant (MDR) Gram-negative bacterial infections in humans. Further, colistin has been also used to prevent and treat Enterobacteriaceae infections in food animals. However, chromosomal mutations and mobile colistin resistance ( mcr ) genes, which confer resistance to colistin, have been detected in bacterial isolates from food...

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PMID: 32764996
DOI: 10.2147/idr.s260766

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