Back to search

Article

<i>In vitro</i> and <i>in vivo</i> efficacy of the combination of colistin and endolysins against clinical strains of Multi-Drug Resistant (MDR) pathogens

2019-06-08

Abstract excerpt

<h4>ABSTRACT</h4> The multidrug resistance (MDR) among pathogenic bacteria is jeopardizing the worth of antimicrobials, which had previously changed medical sciences. In this study, we used bioinformatic tools to identify the endolysins ElyA1 and ElyA2 (GH108-PG3 family) present in the genome of bacteriophages Ab1051Φ and Ab1052Φ, respectively. The muralytic activity of these endolysins over MDR clinical isolates...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
479c5e8e-f0ef-50d9-9428-787653a6d3f4
DOI
10.1101/662460
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
<i>In vitro</i> and <i>in vivo</i> efficacy of the combination of colistin and endolysins against clinical strains of Multi-Drug Resistant (MDR) pathogensDOI 10.1101/662460
<b> A novel enterococcus phage endolysin Lys22 with a wide host range against mixed biofilm of <i>Enterococcus faecalis</i> , <i>Staphylococcus aureus</i> and <i>Acinetobacter baumannii</i> </b>Semantic proximity
Colistin Resistance Mechanism and Management Strategies of Colistin-Resistant <em>Acinetobacter baumannii</em> InfectionsSemantic proximity
Assessing the efficacy of therapeutically promising combination of polymyxin B and triclosan against colistin-resistant <i>Klebsiella pneumoniae</i>Semantic proximity
Characteristic and Potential Therapeutic Effect of Isolated MDR-Acinetobacter Baumannii Lytic PhageSemantic proximity
Antimicrobial resistance during COVID-19 pandemic: alternatives to combat bacterial infections.Semantic proximity
Bacteriophage as a potential biotherapeutics to combat present-day crisis of multi-drug resistant pathogensSemantic proximity
Colistin Resistance Mechanism and Management Strategies of Colistin-Resistant Acinetobacter baumannii InfectionsSemantic proximity
Bacteriophages and Their Host Range in Multidrug-Resistant Bacterial Disease TreatmentSemantic proximity
Synchronic resisto-genesis effects identify most prevalent mechanism in <i>Acinetobacter baumannii</i>Semantic proximity
Novel <i>Bacillus altitudinis</i> endolysin (ArtE2) targeting both Gram-positive and Gram-negative bacteriaSemantic proximity
«Studies <i>in vitro</i> e <i>in vivo</i> of Phage Therapy Medical Products (PTMPs) targeting clinical strains of <i>Klebsiella pneumoniae</i> belonging to the clone ST512»Semantic proximity
A new determination of pan-pathogen antimicrobialsSemantic proximity
Select a neighboring publication to make it the new centre.