Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CpxR overexpression increases the susceptibility of acrB and cpxR double-deleted Salmonella enterica serovar Typhimurium to colistin.

The Journal of antimicrobial chemotherapy - 1 Nov 2018

Zhai Ya-Jun, Huang Hui, Liu Jianhua, Sun Hua-Run, He Dandan, Pan Yu-Shan, Hu Gongzheng

Abstract excerpt

Background: Colistin has been used as the last therapeutic resort for treatment of MDR Gram-negative bacteria infections in humans. The two-component system CpxAR has been reported to contribute to the MDR of bacteria. There may be a more complex network mediated by CpxAR contributing to colistin susceptibility than previously understood. Methods: A series of AcrB or CpxR deletion mutants of a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Colistin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Bacterial

Share to Gene Expression Regulation, Bacterial

Share to Membrane Transport Proteins

Share to Microbial Sensitivity Tests

Share to Salmonella typhimurium

Share to Serogroup

Source

Identifiers

PMID: 30107570
DOI: 10.1093/jac/dky320

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CpxR overexpression increases the susceptibility of acrB and cpxR double-deleted Salmonella enterica serovar Typhimurium to colistin.PMID 30107570Read ↗

Current Update on Intrinsic and Acquired Colistin Resistance Mechanisms in BacteriaSemantic proximity Read ↗

Efflux pump inhibitor CCCP to rescue colistin susceptibility in mcr-1 plasmid-mediated colistin-resistant strains and Gram-negative bacteriaSemantic proximity Read ↗

Mutations in the pmrB gene constitute the major mechanism underlying chromosomally encoded colistin resistance in clinical Escherichia coli.Semantic proximity Read ↗

Salmonella enterica Serovar Typhimurium CpxRA Two-Component System Contributes to Gut Colonization in Salmonella-Induced ColitisSemantic proximity Read ↗

Molecular Mechanisms of Colistin Resistance Among Pandrug-Resistant Isolates of Acinetobacter baumannii with High Case-Fatality Rate in Intensive Care Unit Patients.Semantic proximity Read ↗

Identification of novel mobilized colistin resistance gene <i>mcr</i> -9 in a multidrug-resistant, colistin-susceptible <i>Salmonella enterica</i> serotype Typhimurium isolate using a combination of high-throughput, <i>in silico</i> screening and functional analysisSemantic proximity Read ↗

Mutations in the two component regulator systems PmrAB and PhoPQ give rise to increased colistin resistance in Citrobacter and Enterobacter spp.Semantic proximity Read ↗

Resistance to colistin in Acinetobacter baumannii associated with mutations in the PmrAB two-component system.Semantic proximity Read ↗

Small Molecule Adjuvants Potentiate Colistin Activity and Attenuate Resistance Development in Escherichia coli by Affecting pmrAB SystemSemantic proximity Read ↗

Genetic Alterations Associated with Colistin Resistance Development in Escherichia coli.Semantic proximity Read ↗

Critical role of the RpoE stress response pathway in polymyxin resistance of Escherichia coliSemantic proximity Read ↗

Colistin exposure enhances expression of eptB in colistin-resistant Escherichia coli co-harboring mcr-1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.