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Molecular Mechanisms of Colistin Resistance Among Pandrug-Resistant Isolates of Acinetobacter baumannii with High Case-Fatality Rate in Intensive Care Unit Patients.

Microbial drug resistance (Larchmont, N.Y.) - 1 Nov 2018

Haeili Mehri, Kafshdouz Mahsa, Feizabadi Mohammad Mehdi

Abstract excerpt

Colistin is considered a last-hope antibiotic against extensively drug-resistant isolates of Acinetobacter baumannii. Resistance to colistin has been rarely reported for A. baumannii. Genetic alterations in the PmrA-PmrB two-component system and lipid A biosynthesis genes may be associated with colistin resistance. We investigated molecular mechanisms of colistin resistance in three clinical colistin-resistant...

Topics

Acinetobacter Infections
Acinetobacter baumannii
Amino Acid Substitution
Anti-Bacterial Agents
Bacterial Proteins
Colistin
Drug Resistance, Bacterial
Humans
Intensive Care Units
Microbial Sensitivity Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29590004
DOI: 10.1089/mdr.2017.0397

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