Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CRISPR/Cas9 Editing of the Mouse Thra Gene Produces Models with Variable Resistance to Thyroid Hormone.

Thyroid : official journal of the American Thyroid Association - 1 Jan 2018

Markossian Suzy, Guyot Romain, Richard Sabine, Teixeira Marie, Aguilera Nadine, Bouchet Mathilde, Plateroti Michelina, Guan Wenyue, Gauthier Karine, Aubert Denise, Flamant Frédéric

Abstract excerpt

BACKGROUND: Resistance to thyroid hormone due to THRA mutations (RTHα) is a recently discovered genetic disease, displaying important variability in its clinical presentation. The mutations alter the function of TRα1, one of the two nuclear receptors for thyroid hormone. METHODS: The aim of this study was to understand the relationship between specific THRA mutations and phenotype. CRISPR/Cas9 genome editing was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR-Cas Systems
Share to Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Phenotype

Share to Thyroid Hormone Resistance Syndrome

Source

Identifiers

PMID: 29205102
DOI: 10.1089/thy.2017.0389

Genes

THRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CRISPR/Cas9 Editing of the Mouse Thra Gene Produces Models with Variable Resistance to Thyroid Hormone.PMID 29205102Read ↗

Generation and Characterization of a New Resistance to Thyroid Hormone Mouse Model with Thyroid Hormone Receptor Alpha Gene Mutation.Semantic proximity Read ↗

Clinical Consequences of Mutations in Thyroid Hormone Receptor-α1Semantic proximity Read ↗

TRα receptor mutations extend the spectrum of syndromes of reduced sensitivity to thyroid hormone.Semantic proximity Read ↗

Resistance to thyroid hormone mediated by defective thyroid hormone receptor alpha.Semantic proximity Read ↗

A Novel Mutation in THRA Gene Associated With an Atypical Phenotype of Resistance to Thyroid Hormone.Semantic proximity Read ↗

Resistance to thyroid hormone caused by a mutation in thyroid hormone receptor (TR)α1 and TRα2: clinical, biochemical, and genetic analyses of three related patientsSemantic proximity Read ↗

Severe psychomotor and metabolic damages caused by a mutant thyroid hormone receptor alpha 1 in mice: can patients with a similar mutation be found and treated?Semantic proximity Read ↗

Resistance to thyroid hormone due to defective thyroid receptor alpha.Semantic proximity Read ↗

Resistance to thyroid hormone α, revelation of basic study to clinical consequences.Semantic proximity Read ↗

Contrasting Phenotypes in Resistance to Thyroid Hormone Alpha Correlate with Divergent Properties of Thyroid Hormone Receptor α1 Mutant Proteins.Semantic proximity Read ↗

Two Novel Cases of Resistance to Thyroid Hormone Due to THRA Mutation.Semantic proximity Read ↗

A point mutation in the activation function 2 domain of thyroid hormone receptor alpha1 expressed after CRE-mediated recombination partially recapitulates hypothyroidism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.