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Article

In vivo Functional Consequences of Human THRA Variants Expressed in the Zebrafish.

Thyroid : official journal of the American Thyroid Association - 1 Feb 2017

Marelli Federica, Carra Silvia, Rurale Giuditta, Cotelli Franco, Persani Luca

Abstract excerpt

BACKGROUND: Heterozygous mutations in the thyroid hormone receptor alpha (THRA) gene cause resistance to thyroid hormone alpha (RTHα), a disease characterized by variable manifestations reminiscent of untreated congenital hypothyroidism but a raised triiodothyronine/thyroxine ratio and normal thyrotropin levels. It was recently described that zebrafish embryos expressing a dominant negative (DN) form of thraa...

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Identifiers

PMID: 27809680
DOI: 10.1089/thy.2016.0373

Genes

THRA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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