Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HIV type 1-mediated downregulation of HLA-B57/B5801 proteins on elite suppressor CD4+ T cells.

AIDS research and human retroviruses - 1 Feb 2011

Sampah Maame Efua S, Ceccato Christina M, Blankson Joel N

Abstract excerpt

Elite controllers or suppressors (ES) are HIV-1-infected patients who maintain viral loads of <50 copies/ml without antiretroviral therapy. While HLA-B*57 and B*5801 alleles are overrepresented in ES, many HLA-B*57/B*5801 patients become chronic progressors (CP). We show here that HIV-1 infection...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to CD4-Positive T-Lymphocytes
Share to Down-Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD4 gene

Share to CP gene

Share to HLA-B Antigens

Source

Open in PubMed Open full text

Identifiers

PMID: 20919920
DOI: 10.1089/aid.2010.0144
PMCID: PMC3064525

Genes

CP
CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20919920-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HIV type 1-mediated downregulation of HLA-B*57/B*5801 proteins on elite suppressor CD4+ T cells.PMID 20919920Read ↗

Maintenance of viral suppression in HIV-1-infected HLA-B*57+ elite suppressors despite CTL escape mutations.Semantic proximity Read ↗

HLA class I-restricted T-cell responses may contribute to the control of human immunodeficiency virus infection, but such responses are not always necessary for long-term virus control.Semantic proximity Read ↗

Control of HIV-1 in Elite Suppressors despite Ongoing Replication and Evolution in Plasma VirusSemantic proximity Read ↗

HLA-B*57 elite suppressor and chronic progressor HIV-1 isolates replicate vigorously and cause CD4+ T cell depletion in humanized BLT mice.Semantic proximity Read ↗

HLA-B57/B*5801 Human Immunodeficiency Virus Type 1 Elite Controllers Select for Rare Gag Variants Associated with Reduced Viral Replication Capacity and Strong Cytotoxic T-Lymphotye RecognitionSemantic proximity Read ↗

Memory B Cells, the HLA-B*57 Allele and Natural Control of HIV Infection.Semantic proximity Read ↗

HLA-Associated Viral Mutations Are Common in Human Immunodeficiency Virus Type 1 Elite ControllersSemantic proximity Read ↗

Selective Upregulation of CTLA-4 on CD8+ T Cells Restricted by HLA-B*35Px Renders them to an Exhausted Phenotype in HIV-1 infection.Semantic proximity Read ↗

Both HLA-B*57 and Plasma HIV RNA Levels Contribute to the HIV-Specific CD8 + T Cell Response in HIV ControllersSemantic proximity Read ↗

Early HLA-B*57-restricted CD8+ T lymphocyte responses predict HIV-1 disease progression.Semantic proximity Read ↗

Novel, Cross-Restricted, Conserved, and Immunodominant Cytotoxic T Lymphocyte Epitopes in Slow Progressors in HIV Type 1 InfectionSemantic proximity Read ↗

HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.