Schizotypy, Psychosis Proneness, and the Polygenic Risk for Schizophrenia and Resilience.

doi:10.1093/schbul/sbae161

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Article

Schizotypy, Psychosis Proneness, and the Polygenic Risk for Schizophrenia and Resilience.

Schizophrenia bulletin - 4 Mar 2025

Meller Tina, Lundberg Clara, Maj Carlo, Hoffmann Per, Forstner Andreas J, Nöthen Markus M, Nenadić Igor

Abstract excerpt

BACKGROUND AND HYPOTHESIS: Schizotypy is a well-established phenotype for psychosis proneness and risk. Yet, its genetic underpinnings and relations to genetic bases of the schizophrenia spectrum are not well understood owing to conflicting findings. In a deep phenotyping approach, we hypothesized that genetic markers of risk for and to schizophrenia are differentially associated with (trait-level) dimensions of...

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Topics

Humans
Male
Schizotypal Personality Disorder
Female
Schizophrenia
Multifactorial Inheritance

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Adult

Prodromal Symptoms

Young Adult

Psychotic Disorders

Resilience, Psychological

Genetic Predisposition to Disease

Adolescent

Source

Open in PubMed Open full text

Identifiers

PMID: 40037822
DOI: 10.1093/schbul/sbae161
PMCID: PMC11879570

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