Overarching Immunodominance Patterns and Substantial Diversity in Specificity and Functionality in the Circulating Human Influenza A and B Virus-Specific CD4+ T-Cell Repertoire.

Abstract excerpt

There is limited information on the antigen specificity and functional potential of the influenza virus-specific CD4+ T-cell repertoire in humans. Here, enzyme-linked immunospot assays were used to examine circulating CD4+ T-cell specificities for influenza virus directly ex vivo in healthy adults. Our studies revealed CD4+ T-cell reactivity to multiple influenza virus proteins, including hemagglutinins,...

Topics

• CD4-Positive T-Lymphocytes
• Genetic Variation
• Humans
• Immunodominant Epitopes
• Influenza A virus
• Influenza B virus
• Influenza, Human
• Sensitivity and Specificity