Article
Epitope specific T-cell responses against influenza A in a healthy population.
Immunology - 1 Feb 2016
Savic Miloje, Dembinski Jennifer L, Kim Yohan, Tunheim Gro, Cox Rebecca J, Oftung Fredrik, Peters Bjoern, Mjaaland Siri
Abstract excerpt
Pre-existing human CD4(+) and CD8(+) T-cell-mediated immunity may be a useful correlate of protection against severe influenza disease. Identification and evaluation of common epitopes recognized by T cells with broad cross-reactivity is therefore important to guide universal influenza vaccine development, and to monitor immunological preparedness against pandemics. We have retrieved an optimal combination of MHC...
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