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Increase in Kelch 13 Polymorphisms in Plasmodium falciparum, Southern Rwanda.

Emerging infectious diseases - 1 Jan 2021

Bergmann Clara, van Loon Welmoed, Habarugira Felix, Tacoli Costanza, Jäger Julia C, Savelsberg Darius, Nshimiyimana Fabian, Rwamugema Elias, Mbarushimana Djibril, Ndoli Jules, Sendegeya Augustin, Bayingana Claude, Mockenhaupt Frank P

Abstract excerpt

Artemisinin resistance in Plasmodium falciparum is associated with nonsynonymous mutations in the Kelch 13 (K13) propeller domain. We found that 12.1% (8/66) of clinical P. falciparum isolates from Huye district, Rwanda, exhibited K13 mutations, including R561H, a validated resistance marker. K13 mutations appear to be increasing in this region.

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Identifiers

PMID: 33350925
DOI: 10.3201/eid2701.203527
PMCID: PMC7774571

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