Association of Plasmodium falciparum kelch13 R561H genotypes with delayed parasite clearance in Rwanda: an open-label, single-arm, multicentre, therapeutic efficacy study.

doi:10.1016/S1473-3099(21)00142-0

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Article

Association of Plasmodium falciparum kelch13 R561H genotypes with delayed parasite clearance in Rwanda: an open-label, single-arm, multicentre, therapeutic efficacy study.

The Lancet. Infectious diseases - 1 Aug 2021

Uwimana Aline, Umulisa Noella, Venkatesan Meera, Svigel Samaly S, Zhou Zhiyong, Munyaneza Tharcisse, Habimana Rafiki M, Rucogoza Anicet, Moriarty Leah F, Sandford Ryan, Piercefield Emily, Goldman Ira, Ezema Bryan, Talundzic Eldin, Pacheco M Andreína, Escalante Ananias A, Ngamije Daniel, Mangala Jean-Louis N, Kabera Michee, Munguti Kaendi, Murindahabi Monique, Brieger William, Musanabaganwa Clarisse, Mutesa Leon, Udhayakumar Venkatachalam, Mbituyumuremyi Aimable, Halsey Eric S, Lucchi Naomi W

Abstract excerpt

BACKGROUND: Partial artemisinin resistance is suspected if delayed parasite clearance (ie, persistence of parasitaemia on day 3 after treatment initiation) is observed. Validated markers of artemisinin partial resistance in southeast Asia, Plasmodium falciparum kelch13 (Pfkelch13) R561H and P574L, have been reported in Rwanda but no association with parasite clearance has been observed. We aimed to establish the...

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PMID: 33864801
DOI: 10.1016/S1473-3099(21)00142-0
PMCID: PMC10202849

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