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Article

Miro, a Rho GTPase genetically interacts with Alzheimer's disease-associated genes (Tau, Aβ42andAppl) inDrosophila melanogaster

1 Jan 2020

Abstract excerpt

Miro (mitochondrial Rho GTPases), a mitochondrial outer membrane protein, facilitates mitochondrial axonal transport along the microtubules to facilitate neuronal function. It plays an important role in regulating mitochondrial dynamics (fusion and fission) and cellular energy generation. Thus, Miro might be associated with the key pathologies of several neurodegenerative diseases (NDs) including Alzheimer's...

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PMID: 32747449
DOI: 10.1242/bio.049569

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