Article

Presenilin2 D439A mutation induced the dysfunction of mitochondrial fusion/fission dynamics via regulating Miro2 in Alzheimer’s disease

2023-05-22

Abstract excerpt

<title>Abstract</title> <p>Alzheimer's disease (AD) is an age-related progressive neurodegenerative disease, about 10% of AD patients are called early-onset familial AD (EOFAD), which is mainly linked to the point mutations in genes encoding <italic>Presenilins</italic> (<italic>PS1</italic> and <italic>PS2</italic>). Mutations in PS2 are extremely rare and PS2 mutations have not received enough attention. Recent...

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Literature Corpus work: 976b97e5-6ad6-55bf-8e86-2863cfb7e58a
DOI: 10.21203/rs.3.rs-2921259/v1

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