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Article

The Small GTPase RAC1/CED-10 Is Essential in Maintaining Dopaminergic Neuron Function and Survival Against α-Synuclein-Induced Toxicity.

Molecular neurobiology - 1 Sept 2018

Kim Hanna, Calatayud Carles, Guha Sanjib, Fernández-Carasa Irene, Berkowitz Laura, Carballo-Carbajal Iria, Ezquerra Mario, Fernández-Santiago Rubén, Kapahi Pankaj, Raya Ángel, Miranda-Vizuete Antonio, Lizcano Jose Miguel, Vila Miquel, Caldwell Kim A, Caldwell Guy A, Consiglio Antonella, Dalfo Esther

Abstract excerpt

Parkinson's disease is associated with intracellular α-synuclein accumulation and ventral midbrain dopaminergic neuronal death in the Substantia Nigra of brain patients. The Rho GTPase pathway, mainly linking surface receptors to the organization of the actin and microtubule cytoskeletons, has been suggested to participate to Parkinson's disease pathogenesis. Nevertheless, its exact contribution remains obscure....

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Identifiers

PMID: 29429047
DOI: 10.1007/s12035-018-0881-7
PMCID: PMC6096980

Genes

RAC1

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