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Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids

23 Oct 2015

Abstract excerpt

Human-pluripotent-stem-cell-derived kidney cells (hPSC-KCs) have important potential for disease modelling and regeneration. Whether the hPSC-KCs can reconstitute tissue-specific phenotypes is currently unknown. Here we show that hPSC-KCs self-organize into kidney organoids that functionally recapitulate tissue-specific epithelial physiology, including disease phenotypes after genome editing. In three-dimensional...

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PMID: 26493500
DOI: 10.1038/ncomms9715

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