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Article

Prevalence and phenotypes of APC and MUTYH mutations in patients with multiple colorectal adenomas.

JAMA - 1 Aug 2012

Grover Shilpa, Kastrinos Fay, Steyerberg Ewout W, Cook E Francis, Dewanwala Akriti, Burbidge Lynn Anne, Wenstrup Richard J, Syngal Sapna

Abstract excerpt

CONTEXT: Patients with multiple colorectal adenomas may carry germline mutations in the APC or MUTYH genes. OBJECTIVES: To determine the prevalence of pathogenic APC and MUTYH mutations in patients with multiple colorectal adenomas who had undergone genetic testing and to compare the prevalence and clinical characteristics of APC and MUTYH mutation carriers. DESIGN, SETTING, AND PARTICIPANTS: Cross-sectional...

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Source

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Identifiers

PMID: 22851115
DOI: 10.1001/jama.2012.8780
PMCID: PMC3770297

Genes

APC
MUTYH

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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