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Article

Phenotypic characterization of lung macrophages in asthmatic patients: overexpression of CCL17.

The Journal of allergy and clinical immunology - 1 Dec 2012

Staples Karl J, Hinks Timothy S C, Ward Jon A, Gunn Victoria, Smith Caroline, Djukanović Ratko

Abstract excerpt

BACKGROUND: Studies with monocyte-derived macrophages (MDMs) and animal models have suggested a role for alternatively activated (M2) macrophages in asthmatic inflammation, but in vivo evidence for this phenotype in human asthma is lacking. OBJECTIVE: To characterize the phenotype of lung macrophages from asthmatic patients in relation to disease severity and treatment. METHODS: M2 biomarkers were first...

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Source

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Identifiers

PMID: 22981793
DOI: 10.1016/j.jaci.2012.07.023
PMCID: PMC3805016

Genes

CCL17
CCL22
CCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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