Article
Human asthma phenotypes: from the clinic, to cytokines, and back again.
Immunological reviews - 1 Jul 2011
Bhakta Nirav R, Woodruff Prescott G
Abstract excerpt
A large body of experimental evidence supports the hypothesis that T-helper 2 (Th2) cytokines orchestrate allergic airway inflammation in animal models. However, human asthma is heterogeneous with respect to clinical features, cellular sources of inflammation, and response to common therapies. This disease heterogeneity has been investigated using sputum cytology as well as unbiased clustering approaches using...
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