Article
Association between cerebrospinal fluid dopamine concentrations and catechol-O-methyltransferase gene polymorphisms in forensic autopsy cases of methamphetamine abusers.
Forensic science international - 1 Jan 2017
Matsusue Aya, Ishikawa Takaki, Michiue Tomomi, Waters Brian, Hara Kenji, Kashiwagi Masayuki, Takayama Mio, Ikematsu Natsuki, Kubo Shin-Ichi
Abstract excerpt
Methamphetamine (MA) is an illicit psychostimulant that stimulates the release of catecholamines from sympathetic nerve terminals and is widely abused worldwide. Since catechol-O-methyltransferase (COMT) metabolizes catecholamines and mediates adrenergic, noradrenergic, and dopaminergic signaling responses, we investigated the effects of the COMT polymorphisms rs4633 and rs4680 on cerebrospinal fluid (CSF)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.