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Article

Genetic background mutations drive neural circuit hyperconnectivity in a fragile X syndrome model.

BMC biology - 30 Jul 2020

Kennedy Tyler, Rinker David, Broadie Kendal

Abstract excerpt

BACKGROUND: Neural circuits are initially assembled during development when neurons synapse with potential partners and later refined as appropriate connections stabilize into mature synapses while inappropriate contacts are eliminated. Disruptions to this synaptogenic process impair connectivity optimization and can cause neurodevelopmental disorders. Intellectual disability (ID) and autism spectrum disorder...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32731855
DOI: 10.1186/s12915-020-00817-0
PMCID: PMC7392683

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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