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Article

Temporal requirements of the fragile X mental retardation protein in the regulation of synaptic structure.

Development (Cambridge, England) - 1 Aug 2008

Gatto Cheryl L, Broadie Kendal

Abstract excerpt

Fragile X syndrome (FraX), caused by the loss-of-function of one gene (FMR1), is the most common inherited form of both mental retardation and autism spectrum disorders. The FMR1 product (FMRP) is an mRNA-binding translation regulator that mediates activity-dependent control of synaptic structure and function. To develop any FraX intervention strategy, it is essential to define when and where FMRP loss causes the...

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Identifiers

PMID: 18579676
DOI: 10.1242/dev.022244
PMCID: PMC2753511

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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