Article
Developmental disruption and restoration of brain synaptome architecture in the murine Pax6 neurodevelopmental disease model.
Nature communications - 11 Nov 2022
Tomas-Roca Laura, Qiu Zhen, Fransén Erik, Gokhale Ragini, Bulovaite Edita, Price David J, Komiyama Noboru H, Grant Seth G N
Abstract excerpt
Neurodevelopmental disorders of genetic origin delay the acquisition of normal abilities and cause disabling phenotypes. Nevertheless, spontaneous attenuation and even complete amelioration of symptoms in early childhood and adolescence can occur in many disorders, suggesting that brain circuits possess an intrinsic capacity to overcome the deficits arising from some germline mutations. We examined the molecular...
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