Article

Developmental disruption and restoration of brain synaptome architecture in the Pax6 neurodevelopmental disease model

2022-04-14

Abstract excerpt

<title>Abstract</title> <p>Neurodevelopmental disorders of genetic origin delay the acquisition of normal abilities and cause disabling phenotypes. However, spontaneous attenuation and even complete amelioration of symptoms in early childhood and adolescence occur in many disorders, suggesting that brain circuits possess an intrinsic capacity to overcome some germline mutations. We examined the molecular composit...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 71f2b23f-7f31-516c-85df-7e232f4ad0a4
DOI: 10.21203/rs.3.rs-1508559/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Developmental disruption and restoration of brain synaptome architecture in the Pax6 neurodevelopmental disease modelDOI 10.21203/rs.3.rs-1508559/v1Read

Developmental disruption and restoration of brain synaptome architecture in the murine Pax6 neurodevelopmental disease model.Semantic proximity Read

Experiences are encoded by brainwide reprogramming of synaptome architectureSemantic proximity Read

Molecular Basis for Synaptotagmin-1-Associated Neurodevelopmental DisorderSemantic proximity Read

Remodeling of the postsynaptic proteome in male mice and marmosets during synapse developmentSemantic proximity Read

Neurodevelopmental synaptopathies: Insights from behaviour in rodent models of synapse gene mutations.Semantic proximity Read

Structural and Functional Bioinformatics of Neurexin: A Step Towards Understanding Neurodevelopmental DisordersSemantic proximity Read

Mechanisms Underlying Circuit Dysfunction in Neurodevelopmental Disorders.Semantic proximity Read

Genetic background mutations drive neural circuit hyperconnectivity in a fragile X syndrome model.Semantic proximity Read

The neurodevelopmental spectrum of synaptic vesicle cycling disorders.Semantic proximity Read

Synaptopathies: diseases of the synaptome.Semantic proximity Read

Axonopathy and altered synaptic development in early hippocampal epileptogenesis of Dravet syndromeSemantic proximity Read

SynaptopathyDB: a resource for studying the genetic and synaptic basis of nervous system disordersSemantic proximity Read