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Article

Phenotype microarrays reveal metabolic dysregulations of neurospheres derived from embryonic Ts1Cje mouse model of Down syndrome.

PloS one - 1 Jan 2020

Seth Eryse Amira, Lee Han-Chung, Yusof Hadri Hadi Bin Md, Nordin Norshariza, Cheah Yoke Kqueen, Ho Eric Tatt Wei, Ling King-Hwa, Cheah Pike-See

Abstract excerpt

Down syndrome (DS), is the most common cause of intellectual disability, and is characterized by defective neurogenesis during perinatal development. To identify metabolic aberrations in early neurogenesis, we profiled neurospheres derived from the embryonic brain of Ts1Cje, a mouse model of Down syndrome. High-throughput phenotypic microarray revealed a significant decrease in utilisation of 17 out of 367...

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Identifiers

PMID: 32730314
DOI: 10.1371/journal.pone.0236826
PMCID: PMC7392322

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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