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Article

The cognitive phenotype of Down syndrome: insights from intracellular network analysis.

NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics - 1 Jul 2006

Ma'ayan Avi, Gardiner Katheleen, Iyengar Ravi

Abstract excerpt

Down syndrome (DS) is caused by trisomy of chromosome 21. All individuals with DS exhibit some level of cognitive dysfunction. It is generally accepted that these abnormalities are a result of the upregulation of genes encoded by chromosome 21. Many chromosome 21 proteins are known or predicted to function in critical neurological processes, but typically they function as modulators of these processes, not as key...

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Identifiers

PMID: 16815222
DOI: 10.1016/j.nurx.2006.05.036
PMCID: PMC3032589

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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