Proliferation deficits and gene expression dysregulation in Down's syndrome (Ts1Cje) neural progenitor cells cultured from neurospheres.

Abstract excerpt

Down's syndrome neurophenotypes are characterized by mental retardation and a decreased brain volume. To identify whether deficits in proliferation could be responsible for this phenotype, neural progenitor cells were isolated from the developing E14 neocortex of Down's syndrome partial trisomy Ts1Cje mice and euploid (WT) littermates and grown as neurospheres. Ts1Cje neural progenitors proliferated at a slower...

Topics

• Animals
• Cell Differentiation
• Cell Proliferation
• Cells, Cultured
• Disease Models, Animal
• Down Syndrome
• Gene Expression
• Gene Expression Profiling
• Genotype
• Immunohistochemistry
• Male
• Mice