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DNA Methylation Landscapes of Human Fetal Development

22 Oct 2015

Abstract excerpt

Remodelling the methylome is a hallmark of mammalian development and cell differentiation. However, current knowledge of DNA methylation dynamics in human tissue specification and organ development largely stems from the extrapolation of studies in vitro and animal models. Here, we report on the DNA methylation landscape using the 450k array of four human tissues (amnion, muscle, adrenal and pancreas) during the...

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PMID: 26492326
DOI: 10.1371/journal.pgen.1005583

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