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Chronic Hepatitis B Genotype C Mouse Model with Persistent Covalently Closed Circular DNA.

Viruses - 7 Dec 2024

Seo Deok-Hwa, Hur Wonhee, Won Juhee, Han Ji-Won, Yoon Seung-Kew, Bae Songmee, Kim Kyun-Hwan, Sung Pil-Soo

Abstract excerpt

Hepatitis B virus (HBV) can cause chronic infections, significantly increasing the risk of death from cirrhosis and hepatocellular carcinoma (HCC). A key player in chronic HBV infection is covalently closed circular DNA (cccDNA), a stable episomal form of viral DNA that acts as a persistent reservoir in infected hepatocytes and drives continuous viral replication. Despite the development of several animal models,...

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Identifiers

PMID: 39772197
DOI: 10.3390/v16121890

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